A Melee weapon is used in close combat and has some amount of Range from you that it can hit targets from.

Holding a Melee weapon gives you the following Reaction

Attack of Opportunity

Attack of Opportunity
Tempo:3
Trigger:A Character in your Melee Range moves further away from you (based on your Melee Range).
Action:Make a Strike against that character before they move.
Tags: Reaction Strike

Called Shot

A character with a Melee weapon can make a called shot against a certain body part of a creature if it has it.
The target makes the Strike with Disadvantage.
On a success they, apply one of the following Debuffs for this Combat depending on target location.

Head: Dazed
Eyes: Blind
Ears: Deaf
Hands: Weak
Item: Disarms the Item
Stomach: Shocked
Legs: Restricted